Changes in prescribed drug doses after market introduction

Changes in Capsule and Drug Resistance of Pneumococci after Introduction of PCV7, Japan, 2010–2013

We aimed to clarify changes in serotypes and genotypes mediating β-lactam and macrolide resistance in Streptococcus pneumoniae isolates from Japanese children who had invasive pneumococcal disease (IPD) after the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into Japan; 341 participating general hospitals conducted IPD surveillance during April 2010-March 2013. A total of 300 pn...

Anticipating Market Introduction of Nanotechnology-Enabled Drug Delivery Systems

Nanotechnology-enabled drug delivery systems (NDDS) are associated with high expectations regarding their economic and societal value. NDDS are expected to contribute to important issues in healthcare such as enabling novel pharmaceutical therapies which only target the site of the disease and help to reduce costs of healthcare. To date, more than two dozen NDDS have been developed into markete...

Hematological changes in Tinca tinca after exposure to lethal and sublethal doses of Mercury, Cadmium and Lead

Tench, Tinca tinca, were exposed to three treatments (one acute lethal 96 hrs Lc50/48 hrs and two chronic sublethal 10 and 25% Lc50/504 hrs) each of Mercury, Cadmium and Lead and its behaviour as an indicator of impaired hematology was studied. It was observed that impairments in hematological parameters (increased/decreased Hct, Hb, RBC, WBC and Lct) were reflected in behaviour of fish in the ...

Hematological changes in Tinca tinca after exposure to lethal and sublethal doses of Mercury, Cadmium and Lead

Tench, Tinca tinca, were exposed to three treatments (one acute lethal 96 hrs Lc50/48 hrs and two chronic sublethal 10 and 25% Lc50/504 hrs) each of Mercury, Cadmium and Lead and its behaviour as an indicator of impaired hematology was studied. It was observed that impairments in hematological parameters (increased/decreased Hct, Hb, RBC, WBC and Lct) were reflected in behaviour of fish in the ...

Paludrine: Changes in the Doses